Scientific Information on Unapproved Uses (SIUU) refers to communications from medical product manufacturers that provide health care professionals with truthful, nonmisleading, and scientifically balanced information about unapproved uses of FDA-approved or cleared medical products. These communications are intended to support clinical decision-making by sharing relevant scientific data without promoting those unapproved uses.

SIUU resources are intended exclusively for health care professionals, including physicians, surgeons, researchers, and other qualified medical personnel. Because these materials discuss unapproved uses and scientific data that may require clinical interpretation, they are not designed for patients or the general public.

No, unapproved uses included in SIUU resources have not been evaluated or cleared by the FDA. Health care professionals should rely on their clinical judgment when considering any unapproved use.

Health care professionals can request full-text copies of the included studies at AskResearch@arthrex.com. For questions about this content, contact the Clinical Advisory team (CAT@arthrex.com).

This website features clinical practice guidelines, reference texts, scientific publications, and additional educational content related to unapproved uses of approved or cleared medical products.

This educational content serves to help HCPs understand and evaluate the strengths and weaknesses, validity, and clinical utility of commonly utilized unapproved uses. Always refer to the Directions for Use for product indications, surgical technique, contraindications, warnings, adverse reactions, precautions, sterility, and storage information for Arthrex products.